pI: 7.825 |
Length (AA): 241 |
MW (Da): 27745 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
37 | 223 | 3bho (A) | 36 | 222 | 77.00 | 0 | 1 | 1.71913 | -1.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128813)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G25550 | cleavage/polyadenylation specificity factor |
Babesia bovis | BBOV_III007210 | conserved hypothetical protein |
Brugia malayi | Bm1_28410 | Pre-mrna cleavage factor, identical |
Caenorhabditis elegans | CELE_F43G9.5 | Protein CFIM-1 |
Cryptosporidium hominis | Chro.60436 | hypothetical protein |
Cryptosporidium parvum | cgd6_3810 | NUDIX domain protein; mRNA cleavage factor-like protein Im like, plant+animal group |
Dictyostelium discoideum | DDB_G0269370 | NUDIX hydrolase family protein |
Drosophila melanogaster | Dmel_CG3689 | CG3689 gene product from transcript CG3689-RB |
Echinococcus granulosus | EgrG_000088100 | Cleavage and polyadenylation specificity factor |
Entamoeba histolytica | EHI_077110 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_077220 | pre-mRNA cleavage factor I 25 kDa subunit, putative |
Entamoeba histolytica | EHI_077000 | pre-mRNA cleavage factor I 25 kDa subunit, putative |
Echinococcus multilocularis | EmuJ_000088100 | Cleavage and polyadenylation specificity factor |
Homo sapiens | ENSG00000167005 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 |
Leishmania braziliensis | LbrM.26.0320 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_260280.1 | nucleotide hydrolase, putative |
Leishmania infantum | LinJ.26.0280 | hypothetical protein, conserved |
Leishmania major | LmjF.26.0290 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.26.0290 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04228 | pre-mRNA cleavage factor |
Mus musculus | 68219 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 |
Neospora caninum | NCLIV_004770 | hypothetical protein |
Oryza sativa | 4337444 | Os04g0683100 |
Onchocerca volvulus | OVOC1353 | Cleavage and polyadenylation specificity factor subunit 5 homolog |
Plasmodium berghei | PBANKA_0204400 | cleavage and polyadenylation specificity factor subunit 5, putative |
Plasmodium falciparum | PF3D7_0109200 | cleavage and polyadenylation specificity factor subunit 5, putative |
Plasmodium knowlesi | PKNH_0204600 | cleavage and polyadenylation specificity factor subunit 5, putative |
Plasmodium vivax | PVX_081325 | mRNA cleavage factor-like protein, putative |
Schistosoma japonicum | Sjp_0217610 | ko:K10636 autocrine motility factor receptor, putative |
Schistosoma mansoni | Smp_002190 | pre-mRNA cleavage factor im 25kD subunit |
Schmidtea mediterranea | mk4.008959.02 | |
Schmidtea mediterranea | mk4.003994.01 | Cleavage and polyadenylation specificity factor subunit 5 |
Schmidtea mediterranea | mk4.002056.06 | Cleavage and polyadenylation specificity factor subunit 5 |
Trypanosoma brucei gambiense | Tbg972.7.1630 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.1620 | Cleavage factor I 25 kDa subunit, putative |
Trypanosoma congolense | TcIL3000_7_1170 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509509.40 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508207.220 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_221190 | mrna cleavage factor family protein, putative |
Theileria parva | TP04_0626 | mRNA cleavage factor protein, putative |
Trichomonas vaginalis | TVAG_475950 | pre-mRNA cleavage factor im, 25kD subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1620 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1620 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1620 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1620 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F43G9.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F43G9.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F43G9.5 | Caenorhabditis elegans | sterile | wormbase |
TGME49_221190 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.